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Sildenafil is usually a potent and selective inhibitor of cGMP-particular phosphodiesterase variety five (PDE5), which is liable for degradation of cGMP while in the corpus cavernosum. The molecular construction of sildenafil is similar to that of cGMP and functions to be a aggressive binding agent of PDE5 within the corpus cavernosum, leading to e

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When sexual stimulation brings about regional release of NO, inhibition of PDE5 by sildenafil brings about amplified amounts of cGMP in the corpus cavernosum, resulting in sleek muscle relaxation and inflow of blood to the corpus cavernosum. Sildenafil at advised doses has no effect within the absence of sexual stimulation.i.d.) resulted within a 6

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